CanIsoNet

Gene Name:

Protein Interaction Network

Interaction losses of dMDT
*only proteins having domain-domain interaction information are taken into consideration
Gene
Name		 # of
Interaction*		 # of Missed
Interaction		 Interaction
Lost		 Domain Int
Lost		 Transcript Name dMDT
PTPN12 9 9 PTPN12-CSK Y_phosphatase(58-291)-SH2 PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-GRB2 Y_phosphatase(58-291)-SH2 PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-SRC Y_phosphatase(58-291)-SH2 PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-JAK2 Y_phosphatase(58-291)-SH2 PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-SHC1 Y_phosphatase(58-291)-SH2 PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-FLT3 Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-EGFR Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-PTK2B Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-PTK2 Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-003 ENST00000435495
PTPN12 9 9 PTPN12-CSK Y_phosphatase(58-291)-SH2 PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-GRB2 Y_phosphatase(58-291)-SH2 PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-SRC Y_phosphatase(58-291)-SH2 PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-JAK2 Y_phosphatase(58-291)-SH2 PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-SHC1 Y_phosphatase(58-291)-SH2 PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-FLT3 Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-EGFR Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-PTK2B Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-019 ENST00000407343
PTPN12 9 9 PTPN12-PTK2 Y_phosphatase(58-291)-Pkinase_Tyr PTPN12-019 ENST00000407343

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT

*Transcripts of this gene has been found as dMDT in these disease types

Samples showing lost interactions due to MDT switch
Sample ID Disease Gene Name 1 Gene Name 2 Transcript Name dMDT
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
0031d433-d703-4b2c-9fdf-2920008eb457 Colon.ColoRect-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
9fc223be-56b9-4fde-8981-806a82045236 Colon.ColoRect-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
a7fa7e33-58e4-4463-b697-61a9c58bf9e1 Colon.ColoRect-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
bd33fafa-9922-4efe-9e1d-c8d8f6b8e7cc Colon.ColoRect-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 CSK PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 GRB2 PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 SRC PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 JAK2 PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 SHC1 PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 FLT3 PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 EGFR PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 PTK2B PTPN12-019 ENST00000407343
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA PTPN12 PTK2 PTPN12-019 ENST00000407343
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
3f5e0677-bdc6-4d28-bf1f-c0449fb2cb15 Ovary.Ovary-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 CSK PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 GRB2 PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 SRC PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 JAK2 PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 SHC1 PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 FLT3 PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 EGFR PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 PTK2B PTPN12-003 ENST00000435495
c02d7082-de9b-4d72-b457-f1da55aadad8 Ovary.Ovary-AdenoCA PTPN12 PTK2 PTPN12-003 ENST00000435495