CanIsoNet

Gene Name:

Protein Interaction Network

Interaction losses of dMDT
*only proteins having domain-domain interaction information are taken into consideration
Gene
Name
# of
Interaction*
# of Missed
Interaction
Interaction
Lost
Domain Int
Lost
Transcript Name dMDT
RAPGEF4 5 0 None None RAPGEF4-205 ENST00000540783
RAPGEF4 5 5 RAPGEF4-RAPGEF3 cNMP_binding(63-151)-cNMP_binding RAPGEF4-003 ENST00000397085
RAPGEF4 5 5 RAPGEF4-RAF1 cNMP_binding(63-151)-Pkinase RAPGEF4-003 ENST00000397085
RAPGEF4 5 5 RAPGEF4-RAP1B RasGEF(771-953)-Ras RAPGEF4-003 ENST00000397085
RAPGEF4 5 5 RAPGEF4-RAP1A RasGEF(771-953)-Ras RAPGEF4-003 ENST00000397085
RAPGEF4 5 5 RAPGEF4-APBB1IP RA(671-743)-PH RAPGEF4-003 ENST00000397085
RAPGEF4 5 0 None None RAPGEF4-001 ENST00000397081

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT

*Transcripts of this gene has been found as dMDT in these disease types

Samples showing lost interactions due to MDT switch
Sample ID Disease Gene Name 1 Gene Name 2 Transcript Name dMDT
c34a63cc-746b-4502-a1ff-d7bece07b679 Brain.CNS-Oligo RAPGEF4 - RAPGEF4-205 ENST00000540783
785856FC-D042-4B7F-A137-95B17C59B876 Breast.Breast-AdenoCA RAPGEF4 RAPGEF3 RAPGEF4-003 ENST00000397085
785856FC-D042-4B7F-A137-95B17C59B876 Breast.Breast-AdenoCA RAPGEF4 RAF1 RAPGEF4-003 ENST00000397085
785856FC-D042-4B7F-A137-95B17C59B876 Breast.Breast-AdenoCA RAPGEF4 RAP1B RAPGEF4-003 ENST00000397085
785856FC-D042-4B7F-A137-95B17C59B876 Breast.Breast-AdenoCA RAPGEF4 RAP1A RAPGEF4-003 ENST00000397085
785856FC-D042-4B7F-A137-95B17C59B876 Breast.Breast-AdenoCA RAPGEF4 APBB1IP RAPGEF4-003 ENST00000397085
3fc1c7a8-e5ad-4a4e-89ab-ddf12aa11a3b Breast.Breast-AdenoCA RAPGEF4 - RAPGEF4-205 ENST00000540783
131cd009-c2f2-4e38-a72d-2018af79986a Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
b06483d3-e2c0-4f6f-9af4-871c922eb506 Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
baa1261d-78ae-4a47-8459-2513361ba6de Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
ca134742-0f02-4178-b1bf-c6f7a9ff8cce Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
e8cc9981-3f57-49cc-9779-72d1c50bc59a Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
faad58ae-6000-4ab9-8469-ecd92f0344ff Kidney.Kidney-ChRCC RAPGEF4 - RAPGEF4-001 ENST00000397081
6e37162e-0026-4e3d-96af-db5b502ed2b0 Pancreas.Panc-AdenoCA RAPGEF4 - RAPGEF4-205 ENST00000540783
baecf0b1-419c-497b-8e47-f9053f823c58 Pancreas.Panc-AdenoCA RAPGEF4 - RAPGEF4-205 ENST00000540783
dc2b2e3d-889b-4175-9199-1c909c505b5f Pancreas.Panc-AdenoCA RAPGEF4 - RAPGEF4-205 ENST00000540783