CanIsoNet

Gene Name:

Protein Interaction Network

Interaction losses of dMDT
*only proteins having domain-domain interaction information are taken into consideration
Gene
Name
# of
Interaction*
# of Missed
Interaction
Interaction
Lost
Domain Int
Lost
Transcript Name dMDT
RASGRP2 9 0 None None RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RAF1 C1_1(499-550)-Pkinase RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RASGRP1 C1_1(499-550)-C1_1 RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-APBB1IP C1_1(499-550)-PH RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RRAS RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RAP1B RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-MRAS RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-HRAS RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RAP1A RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-NRAS RasGEF(153-324)-Ras RASGRP2-008 ENST00000377489
RASGRP2 9 9 RASGRP2-RAF1 C1_1(499-550)-Pkinase RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-RASGRP1 C1_1(499-550)-C1_1 RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-APBB1IP C1_1(499-550)-PH RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-RRAS RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-RAP1B RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-MRAS RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-HRAS RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-RAP1A RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-NRAS RasGEF(153-324)-Ras RASGRP2-004 ENST00000421556
RASGRP2 9 9 RASGRP2-RAF1 C1_1(499-550)-Pkinase RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-RASGRP1 C1_1(499-550)-C1_1 RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-APBB1IP C1_1(499-550)-PH RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-RRAS RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-RAP1B RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-MRAS RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-HRAS RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-RAP1A RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487
RASGRP2 9 9 RASGRP2-NRAS RasGEF(153-324)-Ras RASGRP2-009 ENST00000377487

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT

*Transcripts of this gene has been found as dMDT in these disease types

Samples showing lost interactions due to MDT switch
Sample ID Disease Gene Name 1 Gene Name 2 Transcript Name dMDT
2654e816-aab9-4945-ba62-3d6181985463 Blood.Lymph-BNHL RASGRP2 - RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 RAF1 RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 RASGRP1 RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 APBB1IP RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 RRAS RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 RAP1B RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 MRAS RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 HRAS RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 RAP1A RASGRP2-004 ENST00000421556
33fb74dc-e9cf-4cd1-b997-6e1b239fb9e4 Kidney.Kidney-RCC RASGRP2 NRAS RASGRP2-004 ENST00000421556
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Liver.Biliary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver.Liver-HCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver.Liver-HCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-009 ENST00000377487
52c2389d-71f1-4193-bea7-a8487b0dca6a Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-009 ENST00000377487
d6aab8b1-8b8b-443f-b2bc-1539c59efe42 Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-009 ENST00000377487
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary.Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus.Uterus-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489