CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
ACVR1B ACVR1B-INHBA Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-BMP4 Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-GDF11 Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-NODAL Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-INHBB Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-INHBC Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-BMP2 Activin_recp(33-104) Activin_recp(33-104) - TGF_beta
ACVR1B ACVR1B-BAMBI Activin_recp(33-104) Activin_recp(33-104) - Activin_recp

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B INHBA ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B BMP4 ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B GDF11 ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B NODAL ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B INHBB ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B INHBC ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B BMP2 ACVR1B-001 ENST00000542485
310820cc-fc05-45c6-8f04-a44db0828686 Colon.ColoRect-AdenoCA ACVR1B BAMBI ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B INHBA ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B BMP4 ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B GDF11 ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B NODAL ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B INHBB ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B INHBC ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B BMP2 ACVR1B-001 ENST00000542485
82bb01e9-a659-417b-b9e8-831a76277a21 Colon.ColoRect-AdenoCA ACVR1B BAMBI ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B INHBA ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B BMP4 ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B GDF11 ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B NODAL ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B INHBB ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B INHBC ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B BMP2 ACVR1B-001 ENST00000542485
932c2e20-510c-4aed-879e-b69d90710b64 Colon.ColoRect-AdenoCA ACVR1B BAMBI ACVR1B-001 ENST00000542485
Interaction losses with Clinvar proteins
Gene Name
ACVR2B
BMP2
BMP4
GDF11
NODAL