CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
ROCK1 ROCK1-MYL2 Pkinase(76-338) Pkinase(76-338) - EF-hand_1
ROCK1 ROCK1-EPHB3 Pkinase(76-338) Pkinase(76-338) - fn3
ROCK1 ROCK1-MAP2K4 Pkinase(76-338) Pkinase(76-338) - Pkinase
ROCK1 ROCK1-ROCK2 Pkinase(76-338) Pkinase(76-338) - Pkinase
ROCK1 ROCK1-TRIO Pkinase(76-338) Pkinase(76-338) - Pkinase
ROCK1 ROCK1-LIMK2 Pkinase(76-338) Pkinase(76-338) - Pkinase
ROCK1 ROCK1-PRKCZ Pkinase(76-338) Pkinase(76-338) - Pkinase
ROCK1 ROCK1-RAC2 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RND3 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RHOB Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RHOC Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RAC3 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RND1 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-CDC42 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RHOG Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RAC1 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-ARHGAP5 Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-RHOA Pkinase(76-338) Pkinase(76-338) - Ras
ROCK1 ROCK1-VAV3 Pkinase(76-338) Pkinase(76-338) - C1_1
ROCK1 ROCK1-VAV2 Pkinase(76-338) Pkinase(76-338) - C1_1
ROCK1 ROCK1-VAV1 Pkinase(76-338) Pkinase(76-338) - C1_1
ROCK1 ROCK1-SOS2 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF6 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-GAB1 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-RASGRF2 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-FGD2 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-TIAM1 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ABR Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF4 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-TIAM2 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-FGD3 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-NET1 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF18 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-AKAP13 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF2 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-FGD1 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF7 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-ARHGEF16 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-SOS1 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-FGD4 Pkinase(76-338) Pkinase(76-338) - PH
ROCK1 ROCK1-HSP90AA1 Pkinase(76-338) Pkinase(76-338) - HSP90
ROCK1 ROCK1-PARD6A Pkinase(76-338) Pkinase(76-338) - PB1
ROCK1 ROCK1-CDC25A Pkinase(76-338) Pkinase(76-338) - Rhodanese
ROCK1 ROCK1-PTEN Pkinase(76-338) Pkinase(76-338) - DSPc
ROCK1 ROCK1-KDR Pkinase(76-338) Pkinase(76-338) - I-set
ROCK1 ROCK1-ERBB2 Pkinase(76-338) Pkinase(76-338) - Pkinase_Tyr
ROCK1 ROCK1-PPP1R12A Pkinase(76-338) Pkinase(76-338) - Ank_2
ROCK1 ROCK1-MYLPF Pkinase(76-338) Pkinase(76-338) - EF-hand_6
ROCK1 ROCK1-MYL6 Pkinase(76-338) Pkinase(76-338) - EF-hand_6
ROCK1 ROCK1-MYL12B Pkinase(76-338) Pkinase(76-338) - EF-hand_7
ROCK1 ROCK1-MYL9 Pkinase(76-338) Pkinase(76-338) - EF-hand_7
ROCK1 ROCK1-NGEF PH(1121-1312) PH(1121-1312) - SH3_1
ROCK1 ROCK1-ECT2 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-KALRN PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-ARHGEF17 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-ARHGEF3 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-ARHGEF11 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-PLEKHG5 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-ITSN1 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-ARHGEF12 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-MCF2 PH(1121-1312) PH(1121-1312) - RhoGEF
ROCK1 ROCK1-MCF2L PH(1121-1312) PH(1121-1312) - RhoGEF

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MYL2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 EPHB3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MAP2K4 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ROCK2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 TRIO ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 LIMK2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 PRKCZ ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RAC2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RND3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RHOB ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RHOC ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RAC3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RND1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 CDC42 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RHOG ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RAC1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGAP5 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RHOA ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 VAV3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 VAV2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 VAV1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 SOS2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF6 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 GAB1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 RASGRF2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 FGD2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 TIAM1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ABR ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF4 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 TIAM2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 FGD3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 NET1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF18 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 AKAP13 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 FGD1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF7 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF16 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 SOS1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 FGD4 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 HSP90AA1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 PARD6A ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 CDC25A ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 PTEN ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 KDR ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ERBB2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 PPP1R12A ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MYLPF ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MYL6 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MYL12B ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MYL9 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 NGEF ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ECT2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 KALRN ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF17 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF3 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF11 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 PLEKHG5 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ITSN1 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 ARHGEF12 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MCF2 ROCK1-003 ENST00000578051
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA ROCK1 MCF2L ROCK1-003 ENST00000578051
Interaction losses with Clinvar proteins
Gene Name
ARHGEF18
ARHGEF2
CDC42
ERBB2
FGD1
FGD4
GAB1
KDR
MYL2
MYL9
PLEKHG5
PPP1R12A
PTEN
RAC1
RAC2
RAC3
RHOA
SOS1
SOS2
TIAM1
TRIO