CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
ABL1 ABL1-PLCG1 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-BLK SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-STAT3 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-NCK1 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-STAT5B SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-CRK SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-YES1 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-SOCS1 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-LCK SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-GRB2 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-STAT5A SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-CRKL SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-FYN SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-SRC SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-FGR SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-HCK SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-SHC1 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-ABL2 SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-LYN SH2(146-221) SH2(146-221) - SH2
ABL1 ABL1-EPS8 SH2(146-221) SH2(146-221) - SH3_1
ABL1 ABL1-SORBS2 SH2(146-221) SH2(146-221) - SH3_1
ABL1 ABL1-ABI1 SH2(146-221) SH2(146-221) - SH3_1
ABL1 ABL1-CTTN SH2(146-221) SH2(146-221) - SH3_1
ABL1 ABL1-BCAR1 SH2(146-221) SH2(146-221) - SH3_1
ABL1 ABL1-CDON SH2(146-221) SH2(146-221) - fn3
ABL1 ABL1-EPHA3 SH2(146-221) SH2(146-221) - fn3
ABL1 ABL1-EPHB2 SH2(146-221) SH2(146-221) - fn3
ABL1 ABL1-ROBO1 SH2(146-221) SH2(146-221) - fn3
ABL1 ABL1-BCR SH2(146-221) SH2(146-221) - C2
ABL1 ABL1-ATM SH2(146-221) SH2(146-221) - PI3_PI4_kinase
ABL1 ABL1-PRKDC SH2(146-221) SH2(146-221) - PI3_PI4_kinase
ABL1 ABL1-ATR SH2(146-221) SH2(146-221) - PI3_PI4_kinase
ABL1 ABL1-MTOR SH2(146-221) SH2(146-221) - PI3_PI4_kinase
ABL1 ABL1-PDGFRB SH2(146-221) SH2(146-221) - Pkinase_Tyr
ABL1 ABL1-NTRK1 SH2(146-221) SH2(146-221) - Pkinase_Tyr
ABL1 ABL1-DNM2 SH3_1(86-132) SH3_1(86-132) - PH
ABL1 ABL1-SOS1 SH3_1(86-132) SH3_1(86-132) - PH
ABL1 ABL1-UBC SH3_1(86-132) SH3_1(86-132) - ubiquitin
ABL1 ABL1-TP53 SH3_1(86-132) SH3_1(86-132) - P53
ABL1 ABL1-TP73 SH3_1(86-132) SH3_1(86-132) - P53
ABL1 ABL1-NFKBIA SH3_1(86-132) SH3_1(86-132) - Ank_2
ABL1 ABL1-SLIT1 SH3_1(86-132) SH3_1(86-132) - LRR_4
ABL1 ABL1-MAPK12 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAPK1 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAPK14 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-CDK4 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAPK3 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-CDK6 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-CDK2 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAPK11 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAPK8 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAP4K1 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-CDK5 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-MAP2K6 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - Pkinase
ABL1 ABL1-ABI2 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - SH3_9
ABL1 ABL1-BAIAP2 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - SH3_9
ABL1 ABL1-NEDD9 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - SH3_9
ABL1 ABL1-PSTPIP1 Pkinase_Tyr(261-511) Pkinase_Tyr(261-511) - SH3_9

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 PLCG1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 BLK ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 STAT3 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 NCK1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 STAT5B ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CRK ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 YES1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SOCS1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 LCK ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 GRB2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 STAT5A ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CRKL ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 FYN ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SRC ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 FGR ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 HCK ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SHC1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ABL2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 LYN ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 EPS8 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SORBS2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ABI1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CTTN ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 BCAR1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CDON ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 EPHA3 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 EPHB2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ROBO1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 BCR ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ATM ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 PRKDC ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ATR ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MTOR ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 PDGFRB ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 NTRK1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 DNM2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SOS1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 UBC ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 TP53 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 TP73 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 NFKBIA ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 SLIT1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK12 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK14 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CDK4 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK3 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CDK6 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CDK2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK11 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAPK8 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAP4K1 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 CDK5 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 MAP2K6 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 ABI2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 BAIAP2 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 NEDD9 ABL1-003 ENST00000393293
cf1625b4-f30b-487f-8e2c-2866af730c7f Ovary.Ovary-AdenoCA ABL1 PSTPIP1 ABL1-003 ENST00000393293
Interaction losses with Clinvar proteins
Gene Name
ABL1
ATM
ATR
BCR
BLK
CDK4
CDK5
CDK6
CDON
DNM2
EPHB2
EPS8
LCK
MAPK1
MTOR
NFKBIA
NTRK1
PDGFRB
PRKDC
PSTPIP1
SOCS1
SOS1
SRC
STAT3
STAT5B
TP53
TP73