dMDT Interaction Network
Protein interaction losses due to MDT switch
| Gene Name | Interaction Lost | Lost Domain (Region) | Lost Domain - Domain Interaction |
|---|---|---|---|
| ADAM10 | ADAM10-ADAM17 | Disintegrin(466-547) | Disintegrin(466-547) - Disintegrin |
| ADAM10 | ADAM10-ADAM12 | Disintegrin(466-547) | Disintegrin(466-547) - Disintegrin |
| ADAM10 | ADAM10-LRIG1 | Reprolysin(220-456) | Reprolysin(220-456) - LRR_8 |
Network Density Score: %
The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
| Sample ID | Disease Type | Gene Name 1 | Gene Name 2 | Transcript Name | dMDT |
|---|---|---|---|---|---|
| 37725090-996e-4ab2-bbf6-dc3d2970e387 | Esophagus.Eso-AdenoCA | ADAM10 | ADAM17 | ADAM10-013 | ENST00000558004 |
| 37725090-996e-4ab2-bbf6-dc3d2970e387 | Esophagus.Eso-AdenoCA | ADAM10 | ADAM12 | ADAM10-013 | ENST00000558004 |
| 37725090-996e-4ab2-bbf6-dc3d2970e387 | Esophagus.Eso-AdenoCA | ADAM10 | LRIG1 | ADAM10-013 | ENST00000558004 |