CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
CDK4 CDK4-PSMD10 Pkinase(7-295) Pkinase(7-295) - Ank
CDK4 CDK4-CDKN2A Pkinase(7-295) Pkinase(7-295) - Ank
CDK4 CDK4-CDK13 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDC7 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK7 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK6 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK14 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK2 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK19 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK8 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK1 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK3 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-CDK5 Pkinase(7-295) Pkinase(7-295) - Pkinase
CDK4 CDK4-PPARGC1A Pkinase(7-295) Pkinase(7-295) - RRM_1
CDK4 CDK4-CCND1 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNA1 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNB1 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNH Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCND2 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNE1 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNA2 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNB2 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNE2 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCND3 Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNY Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNF Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-CCNC Pkinase(7-295) Pkinase(7-295) - Cyclin_N
CDK4 CDK4-HSP90AA1 Pkinase(7-295) Pkinase(7-295) - HSP90
CDK4 CDK4-UBC Pkinase(7-295) Pkinase(7-295) - ubiquitin
CDK4 CDK4-NBN Pkinase(7-295) Pkinase(7-295) - FHA
CDK4 CDK4-CDC25A Pkinase(7-295) Pkinase(7-295) - Rhodanese
CDK4 CDK4-CDC25C Pkinase(7-295) Pkinase(7-295) - Rhodanese
CDK4 CDK4-TNRC6C Pkinase(7-295) Pkinase(7-295) - UBA
CDK4 CDK4-CDKN1B Pkinase(7-295) Pkinase(7-295) - CDI
CDK4 CDK4-CDKN1A Pkinase(7-295) Pkinase(7-295) - CDI
CDK4 CDK4-CDKN1C Pkinase(7-295) Pkinase(7-295) - CDI
CDK4 CDK4-CDC37 Pkinase(7-295) Pkinase(7-295) - CDC37_N
CDK4 CDK4-ABL1 Pkinase(7-295) Pkinase(7-295) - Pkinase_Tyr
CDK4 CDK4-CDKN2C Pkinase(7-295) Pkinase(7-295) - Ank_2
CDK4 CDK4-CDKN2B Pkinase(7-295) Pkinase(7-295) - Ank_2
CDK4 CDK4-NOTCH1 Pkinase(7-295) Pkinase(7-295) - Ank_2
CDK4 CDK4-CDKN2D Pkinase(7-295) Pkinase(7-295) - Ank_2

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 PSMD10 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN2A CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK13 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDC7 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK7 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK6 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK14 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK2 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK19 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK8 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK3 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDK5 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 PPARGC1A CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCND1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNA1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNB1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNH CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCND2 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNE1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNA2 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNB2 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNE2 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCND3 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNY CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNF CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CCNC CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 HSP90AA1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 UBC CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 NBN CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDC25A CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDC25C CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 TNRC6C CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN1B CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN1A CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN1C CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDC37 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 ABL1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN2C CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN2B CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 NOTCH1 CDK4-004 ENST00000549606
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA CDK4 CDKN2D CDK4-004 ENST00000549606
Interaction losses with Clinvar proteins
Gene Name
ABL1
CCND1
CCND2
CCNF
CDK13
CDK19
CDK4
CDK5
CDK6
CDK8
CDKN1B
CDKN1C
CDKN2A
NBN
NOTCH1