CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
CHN2 CHN2-SOS2 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ARHGEF6 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-RASGRF2 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-FGD2 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-TIAM1 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ARHGEF4 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-TIAM2 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-FGD3 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-NET1 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ARHGEF18 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-AKAP13 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ARHGEF2 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-FGD1 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ARHGEF16 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-SOS1 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-FGD4 C1_1(215-266) C1_1(215-266) - PH
CHN2 CHN2-ECT2 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-KALRN C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-ARHGEF17 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-ARHGEF3 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-ARHGEF11 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-PLEKHG5 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-ARHGEF12 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-MCF2 C1_1(215-266) C1_1(215-266) - RhoGEF
CHN2 CHN2-RHOV RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOQ RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RAC2 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOF RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOB RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOC RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RAC3 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOD RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-CDC42 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOJ RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOT2 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOBTB1 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOG RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RAC1 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOT1 RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOU RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOH RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOA RhoGAP(291-441) RhoGAP(291-441) - Ras
CHN2 CHN2-RHOBTB2 RhoGAP(291-441) RhoGAP(291-441) - Ras

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 SOS2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF6 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RASGRF2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 FGD2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 TIAM1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF4 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 TIAM2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 FGD3 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 NET1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF18 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 AKAP13 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 FGD1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF16 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 SOS1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 FGD4 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ECT2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 KALRN CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF17 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF3 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF11 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 PLEKHG5 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 ARHGEF12 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 MCF2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOV CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOQ CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RAC2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOF CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOB CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOC CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RAC3 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOD CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 CDC42 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOJ CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOT2 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOBTB1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOG CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RAC1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOT1 CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOU CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOH CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOA CHN2-010 ENST00000439384
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA CHN2 RHOBTB2 CHN2-010 ENST00000439384
Interaction losses with Clinvar proteins
Gene Name
ARHGEF18
ARHGEF2
CDC42
FGD1
FGD4
PLEKHG5
RAC1
RAC2
RAC3
RHOA
RHOBTB2
RHOH
SOS1
SOS2
TIAM1
TRIO