CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction lost due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain<-->Domain Interaction
KSR1 KSR1-MAPK1 Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-RAF1 Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-MAP2K2 Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-MAPK3 Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-BRAF Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-MAP2K1 Pkinase(613-878) Pkinase(613-878)--Pkinase
KSR1 KSR1-CNKSR1 Pkinase(613-878) Pkinase(613-878)--PH
KSR1 KSR1-HSP90AA1 Pkinase(613-878) Pkinase(613-878)--HSP90

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Protein Interaction Lost due to the MDT switch in all disease types
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 MAPK1 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 RAF1 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 MAP2K2 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 MAPK3 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 BRAF KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 MAP2K1 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 CNKSR1 KSR1-005 ENST00000580163
803797c0-ed91-4480-be54-b9668505bedb Lymph-BNHL KSR1 HSP90AA1 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 MAPK1 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 RAF1 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 MAP2K2 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 MAPK3 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 BRAF KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 MAP2K1 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 CNKSR1 KSR1-005 ENST00000580163
a2d0eeb7-b227-4795-a3f6-0c0830003a5a Lymph-BNHL KSR1 HSP90AA1 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 MAPK1 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 RAF1 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 MAP2K2 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 MAPK3 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 BRAF KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 MAP2K1 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 CNKSR1 KSR1-005 ENST00000580163
41e90e6f-0afe-433e-a13d-cc5fc758c55b Liver-HCC KSR1 HSP90AA1 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 MAPK1 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 RAF1 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 MAP2K2 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 MAPK3 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 BRAF KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 MAP2K1 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 CNKSR1 KSR1-005 ENST00000580163
8fb8dcc2-ddb8-11e4-ad8f-5ed8e2d07381 Liver-HCC KSR1 HSP90AA1 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 MAPK1 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 RAF1 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 MAP2K2 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 MAPK3 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 BRAF KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 MAP2K1 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 CNKSR1 KSR1-005 ENST00000580163
15c0fde7-d2b9-434d-81be-196d49244f8d Ovary-AdenoCA KSR1 HSP90AA1 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
1e4be071-ebc0-4eba-b66f-abd178f60ea1 Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
2b6b5499-a092-4fb6-a670-ad599db4f2cb Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
74d3061c-1507-45bb-9aea-f8a8046f8046 Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
7c23f39f-6b3f-41d8-bb17-c35788b2b060 Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
7eb0de2d-f2b7-4bbd-bfdf-38f9205dfcd9 Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 MAPK1 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 RAF1 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 MAP2K2 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 MAPK3 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 BRAF KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 MAP2K1 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 CNKSR1 KSR1-005 ENST00000580163
a4f282c0-b938-44b1-a34d-bd7e2ece4dc5 Skin-Melanoma KSR1 HSP90AA1 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 MAPK1 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 RAF1 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 MAP2K2 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 MAPK3 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 BRAF KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 MAP2K1 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 CNKSR1 KSR1-005 ENST00000580163
95698d6f-5687-4261-a6f4-30a349f74baf Stomach-AdenoCA KSR1 HSP90AA1 KSR1-005 ENST00000580163
Protein Interaction Lost with Proteins annotated in Clinvar
Gene Name
BRAF
MAP2K1
MAP2K2
MAPK1
RAF1