CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
KSR1 KSR1-MAPK1 Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-RAF1 Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-MAP2K2 Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-MAPK3 Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-BRAF Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-MAP2K1 Pkinase(613-878) Pkinase(613-878) - Pkinase
KSR1 KSR1-CNKSR1 Pkinase(613-878) Pkinase(613-878) - PH
KSR1 KSR1-HSP90AA1 Pkinase(613-878) Pkinase(613-878) - HSP90

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 MAPK1 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 RAF1 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 MAP2K2 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 MAPK3 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 BRAF KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 MAP2K1 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 CNKSR1 KSR1-017 ENST00000580430
b0688dd8-0d35-4717-a406-78568db1ca2b Blood.Lymph-BNHL KSR1 HSP90AA1 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 MAPK1 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 RAF1 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 MAP2K2 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 MAPK3 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 BRAF KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 MAP2K1 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 CNKSR1 KSR1-017 ENST00000580430
82a1c742-2d97-4c7a-bf1d-ca0233c60b6c Colon.ColoRect-AdenoCA KSR1 HSP90AA1 KSR1-017 ENST00000580430
Interaction losses with Clinvar proteins
Gene Name
BRAF
MAP2K1
MAP2K2
MAPK1
RAF1