CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
MAPK3 MAPK3-NFKB1 Pkinase(42-330) Pkinase(42-330) - Ank
MAPK3 MAPK3-DAPK1 Pkinase(42-330) Pkinase(42-330) - Ank
MAPK3 MAPK3-GHR Pkinase(42-330) Pkinase(42-330) - fn3
MAPK3 MAPK3-IGF1R Pkinase(42-330) Pkinase(42-330) - fn3
MAPK3 MAPK3-IL2RG Pkinase(42-330) Pkinase(42-330) - fn3
MAPK3 MAPK3-MAPK1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MAPK14 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RAF1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RPS6KA5 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MAP2K2 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-PRKCQ Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-CDK2 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-BRAF Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MAP2K1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MAPK7 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-KSR1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-PRKCD Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RPS6KA4 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MKNK1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RPS6KA3 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-MAP3K1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-PRKCA Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RPS6KA2 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-RPS6KA1 Pkinase(42-330) Pkinase(42-330) - Pkinase
MAPK3 MAPK3-HRAS Pkinase(42-330) Pkinase(42-330) - Ras
MAPK3 MAPK3-RAC1 Pkinase(42-330) Pkinase(42-330) - Ras
MAPK3 MAPK3-RAP1A Pkinase(42-330) Pkinase(42-330) - Ras
MAPK3 MAPK3-NRAS Pkinase(42-330) Pkinase(42-330) - Ras
MAPK3 MAPK3-RHOA Pkinase(42-330) Pkinase(42-330) - Ras
MAPK3 MAPK3-GAB1 Pkinase(42-330) Pkinase(42-330) - PH
MAPK3 MAPK3-IRS1 Pkinase(42-330) Pkinase(42-330) - PH
MAPK3 MAPK3-GAB2 Pkinase(42-330) Pkinase(42-330) - PH
MAPK3 MAPK3-IRS2 Pkinase(42-330) Pkinase(42-330) - PH
MAPK3 MAPK3-SOS1 Pkinase(42-330) Pkinase(42-330) - PH
MAPK3 MAPK3-UBC Pkinase(42-330) Pkinase(42-330) - ubiquitin
MAPK3 MAPK3-ISG15 Pkinase(42-330) Pkinase(42-330) - ubiquitin
MAPK3 MAPK3-DUSP16 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP1 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP4 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP6 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP2 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP8 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP10 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP5 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP7 Pkinase(42-330) Pkinase(42-330) - Rhodanese
MAPK3 MAPK3-DUSP3 Pkinase(42-330) Pkinase(42-330) - DSPc
MAPK3 MAPK3-PTP4A3 Pkinase(42-330) Pkinase(42-330) - DSPc
MAPK3 MAPK3-CASP8 Pkinase(42-330) Pkinase(42-330) - DED
MAPK3 MAPK3-BSG Pkinase(42-330) Pkinase(42-330) - I-set
MAPK3 MAPK3-MET Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-LCK Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-JAK1 Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-RET Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-ABL1 Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-JAK2 Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-MATK Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-JAK3 Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-LYN Pkinase(42-330) Pkinase(42-330) - Pkinase_Tyr
MAPK3 MAPK3-NFKBIA Pkinase(42-330) Pkinase(42-330) - Ank_2

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 NFKB1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DAPK1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 GHR MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 IGF1R MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 IL2RG MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAPK1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAPK14 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RAF1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RPS6KA5 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAP2K2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 PRKCQ MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 CDK2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 BRAF MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAP2K1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAPK7 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 KSR1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 PRKCD MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RPS6KA4 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MKNK1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RPS6KA3 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MAP3K1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 PRKCA MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RPS6KA2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RPS6KA1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 HRAS MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RAC1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RAP1A MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 NRAS MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RHOA MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 GAB1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 IRS1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 GAB2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 IRS2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 SOS1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 UBC MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 ISG15 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP16 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP4 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP6 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP8 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP10 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP5 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP7 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 DUSP3 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 PTP4A3 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 CASP8 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 BSG MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MET MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 LCK MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 JAK1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 RET MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 ABL1 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 JAK2 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 MATK MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 JAK3 MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 LYN MAPK3-011 ENST00000395200
39178b5c-3a32-4e85-a2ca-a4e06097718a Blood.Lymph-CLL MAPK3 NFKBIA MAPK3-011 ENST00000395200
Interaction losses with Clinvar proteins
Gene Name
ABL1
BRAF
BSG
CASP8
DUSP6
GAB1
GHR
HRAS
IGF1R
IL2RG
IRS1
IRS2
ISG15
JAK1
JAK2
JAK3
LCK
MAP2K1
MAP2K2
MAP3K1
MAPK1
MET
NFKB1
NFKBIA
NRAS
PRKCD
RAC1
RAF1
RET
RHOA
RPS6KA3
SOS1