CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
NGEF NGEF-CHN2 SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-BLK SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-YES1 SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-LCK SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-FYN SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-SRC SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-FGR SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-HCK SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-CHN1 SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-LYN SH3_1(621-665) SH3_1(621-665) - SH2
NGEF NGEF-TRIP10 SH3_1(621-665) SH3_1(621-665) - SH3_1
NGEF NGEF-SRGAP3 SH3_1(621-665) SH3_1(621-665) - SH3_1
NGEF NGEF-ARHGAP9 SH3_1(621-665) SH3_1(621-665) - SH3_1
NGEF NGEF-ARAP3 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARHGAP22 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARHGAP15 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARAP2 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-BCR SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ABR SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ROCK2 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARHGAP12 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARAP1 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARHGAP24 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ROCK1 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-ARHGAP25 SH3_1(621-665) SH3_1(621-665) - PH
NGEF NGEF-KALRN SH3_1(621-665) SH3_1(621-665) - RhoGEF
NGEF NGEF-ARHGEF1 SH3_1(621-665) SH3_1(621-665) - RhoGEF
NGEF NGEF-ARHGEF12 SH3_1(621-665) SH3_1(621-665) - RhoGEF
NGEF NGEF-EPHA5 SH3_1(621-665) SH3_1(621-665) - Pkinase_Tyr
NGEF NGEF-EPHA1 SH3_1(621-665) SH3_1(621-665) - Pkinase_Tyr
NGEF NGEF-EPHA4 SH3_1(621-665) SH3_1(621-665) - Pkinase_Tyr
NGEF NGEF-EPHA3 SH3_1(621-665) SH3_1(621-665) - Pkinase_Tyr
NGEF NGEF-EPHA2 SH3_1(621-665) SH3_1(621-665) - Pkinase_Tyr
NGEF NGEF-RHOV RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOQ RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RAC2 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOF RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOB RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOC RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RAC3 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOD RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-CDC42 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOJ RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOT2 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOBTB1 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOG RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RAC1 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOT1 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOU RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOH RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-ARHGAP5 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-ARHGAP35 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOA RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-RHOBTB2 RhoGEF(278-456) RhoGEF(278-456) - Ras
NGEF NGEF-ARHGAP29 RhoGEF(278-456) RhoGEF(278-456) - C1_1
NGEF NGEF-RACGAP1 RhoGEF(278-456) RhoGEF(278-456) - C1_1
NGEF NGEF-GNA13 RhoGEF(278-456) RhoGEF(278-456) - G-alpha
NGEF NGEF-ARHGAP26 RhoGEF(278-456) RhoGEF(278-456) - SH3_9
NGEF NGEF-ARHGAP32 RhoGEF(278-456) RhoGEF(278-456) - SH3_9
NGEF NGEF-ARHGAP33 RhoGEF(278-456) RhoGEF(278-456) - SH3_9
NGEF NGEF-ARHGAP10 RhoGEF(278-456) RhoGEF(278-456) - SH3_9
NGEF NGEF-SRGAP1 RhoGEF(278-456) RhoGEF(278-456) - SH3_9

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF CHN2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF BLK NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF YES1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF LCK NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF FYN NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF SRC NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF FGR NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF HCK NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF CHN1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF LYN NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF TRIP10 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF SRGAP3 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP9 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARAP3 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP22 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP15 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARAP2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF BCR NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ABR NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ROCK2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP12 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARAP1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP24 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ROCK1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP25 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF KALRN NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGEF1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGEF12 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF EPHA5 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF EPHA1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF EPHA4 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF EPHA3 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF EPHA2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOV NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOQ NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RAC2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOF NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOB NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOC NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RAC3 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOD NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF CDC42 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOJ NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOT2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOBTB1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOG NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RAC1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOT1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOU NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOH NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP5 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP35 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOA NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RHOBTB2 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP29 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF RACGAP1 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF GNA13 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP26 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP32 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP33 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF ARHGAP10 NGEF-006 ENST00000420650
62f673a5-a31a-4fb5-9e9e-0ee95ba0a377 Pancreas.Panc-AdenoCA NGEF SRGAP1 NGEF-006 ENST00000420650
Interaction losses with Clinvar proteins
Gene Name
ARHGAP26
ARHGEF1
BCR
BLK
CDC42
CHN1
EPHA2
LCK
RAC1
RAC2
RAC3
RACGAP1
RHOA
RHOBTB2
RHOH
SRC
SRGAP1