dMDT Interaction Network
Protein interaction losses due to MDT switch
| Gene Name | Interaction Lost | Lost Domain (Region) | Lost Domain - Domain Interaction |
|---|---|---|---|
| NUP50 | NUP50-RAN | Ran_BP1(352-465) | Ran_BP1(352-465) - Ras |
| NUP50 | NUP50-RANBP2 | Ran_BP1(352-465) | Ran_BP1(352-465) - Ran_BP1 |
| NUP50 | NUP50-XPO1 | Ran_BP1(352-465) | Ran_BP1(352-465) - CRM1_C |
| NUP50 | NUP50-KPNB1 | NUP50(2-69) | NUP50(2-69) - Arm |
| NUP50 | NUP50-KPNA2 | NUP50(2-69) | NUP50(2-69) - Arm |
| NUP50 | NUP50-KPNA1 | NUP50(2-69) | NUP50(2-69) - Arm |
Network Density Score: %
The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
| Sample ID | Disease Type | Gene Name 1 | Gene Name 2 | Transcript Name | dMDT |
|---|---|---|---|---|---|
| SRR19243457 | Alzheimer's disease | NUP50 | RAN | NUP50-010 | ENST00000430547 |
| SRR19243457 | Alzheimer's disease | NUP50 | RANBP2 | NUP50-010 | ENST00000430547 |
| SRR19243457 | Alzheimer's disease | NUP50 | XPO1 | NUP50-010 | ENST00000430547 |
| SRR19243457 | Alzheimer's disease | NUP50 | KPNB1 | NUP50-010 | ENST00000430547 |
| SRR19243457 | Alzheimer's disease | NUP50 | KPNA2 | NUP50-010 | ENST00000430547 |
| SRR19243457 | Alzheimer's disease | NUP50 | KPNA1 | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | RAN | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | RANBP2 | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | XPO1 | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | KPNB1 | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | KPNA2 | NUP50-010 | ENST00000430547 |
| SRR19243470 | Alzheimer's disease | NUP50 | KPNA1 | NUP50-010 | ENST00000430547 |
Interaction losses with Clinvar proteins
| Gene Name |
|---|
| RANBP2 |