CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
PMS1 PMS1-MLH1 DNA_mis_repair(210-338) DNA_mis_repair(210-338) - DNA_mis_repair
PMS1 PMS1-MSH2 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V
PMS1 PMS1-MSH6 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V
PMS1 PMS1-MSH4 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V
PMS1 PMS1-MSH3 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V
PMS1 PMS1-MSH5 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V
PMS1 PMS1-MSH5-SAPCD1 HATPase_c_3(22-122) HATPase_c_3(22-122) - MutS_V

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MLH1 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH2 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH6 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH4 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH3 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH5 PMS1-016 ENST00000452382
e54b7e44-82a3-4016-bc32-129799097b4c Uterus.Uterus-AdenoCA PMS1 MSH5-SAPCD1 PMS1-016 ENST00000452382
Interaction losses with Clinvar proteins
Gene Name
MLH1
MSH2
MSH3
MSH4
MSH5
MSH6
PMS1