CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
POLR2E POLR2E-POLR1A RNA_pol_Rpb5_C(137-210) RNA_pol_Rpb5_C(137-210) - RNA_pol_Rpb1_1
POLR2E POLR2E-POLR3A RNA_pol_Rpb5_C(137-210) RNA_pol_Rpb5_C(137-210) - RNA_pol_Rpb1_1
POLR2E POLR2E-POLR2A RNA_pol_Rpb5_C(137-210) RNA_pol_Rpb5_C(137-210) - RNA_pol_Rpb1_5
POLR2E POLR2E-POLR2I RNA_pol_Rpb5_N(1-95) RNA_pol_Rpb5_N(1-95) - TFIIS_C
POLR2E POLR2E-POLR3K RNA_pol_Rpb5_N(1-95) RNA_pol_Rpb5_N(1-95) - TFIIS_C
POLR2E POLR2E-TCEA2 RNA_pol_Rpb5_N(1-95) RNA_pol_Rpb5_N(1-95) - TFIIS_C
POLR2E POLR2E-TCEA3 RNA_pol_Rpb5_N(1-95) RNA_pol_Rpb5_N(1-95) - TFIIS_C
POLR2E POLR2E-TCEA1 RNA_pol_Rpb5_N(1-95) RNA_pol_Rpb5_N(1-95) - TFIIS_C

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E POLR1A POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E POLR3A POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E POLR2A POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E POLR2I POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E POLR3K POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E TCEA2 POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E TCEA3 POLR2E-002 ENST00000591767
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA POLR2E TCEA1 POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E POLR1A POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E POLR3A POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E POLR2A POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E POLR2I POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E POLR3K POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E TCEA2 POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E TCEA3 POLR2E-002 ENST00000591767
87ddacee-93c2-4a9a-9e53-3af7fe5c0886 Kidney.Kidney-RCC POLR2E TCEA1 POLR2E-002 ENST00000591767
Interaction losses with Clinvar proteins
Gene Name
POLR1A
POLR2A
POLR3A
POLR3K