CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
PRKCA PRKCA-ACTB Pkinase(340-583) Pkinase(340-583) - Actin
PRKCA PRKCA-NFKB1 Pkinase(340-583) Pkinase(340-583) - Ank
PRKCA PRKCA-ITGB4 Pkinase(340-583) Pkinase(340-583) - fn3
PRKCA PRKCA-MAPK1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-RPS6KB1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-RAF1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-MAPK3 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-PRKCG Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-BRAF Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-PRKCB Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-PRKCE Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-ADRBK1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-PRKCD Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-PDPK1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-CHUK Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-CDK1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-CHEK1 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-RPS6KA2 Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-IKBKB Pkinase(340-583) Pkinase(340-583) - Pkinase
PRKCA PRKCA-HRAS Pkinase(340-583) Pkinase(340-583) - Ras
PRKCA PRKCA-RAC1 Pkinase(340-583) Pkinase(340-583) - Ras
PRKCA PRKCA-RAB4A Pkinase(340-583) Pkinase(340-583) - Ras
PRKCA PRKCA-RHOA Pkinase(340-583) Pkinase(340-583) - Ras
PRKCA PRKCA-ELAVL1 Pkinase(340-583) Pkinase(340-583) - RRM_1
PRKCA PRKCA-CCNB1 Pkinase(340-583) Pkinase(340-583) - Cyclin_N
PRKCA PRKCA-PLD1 Pkinase(340-583) Pkinase(340-583) - PH
PRKCA PRKCA-TEC Pkinase(340-583) Pkinase(340-583) - PH
PRKCA PRKCA-GRB10 Pkinase(340-583) Pkinase(340-583) - PH
PRKCA PRKCA-SOS1 Pkinase(340-583) Pkinase(340-583) - PH
PRKCA PRKCA-GRB7 Pkinase(340-583) Pkinase(340-583) - PH
PRKCA PRKCA-UBC Pkinase(340-583) Pkinase(340-583) - ubiquitin
PRKCA PRKCA-VCAM1 Pkinase(340-583) Pkinase(340-583) - I-set
PRKCA PRKCA-NRG2 Pkinase(340-583) Pkinase(340-583) - I-set
PRKCA PRKCA-EGFR Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-FER Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-KIT Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-YES1 Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-FES Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-PTK2B Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-LCK Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-ERBB4 Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-FYN Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-RET Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-SRC Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-JAK2 Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-LYN Pkinase(340-583) Pkinase(340-583) - Pkinase_Tyr
PRKCA PRKCA-NFKBIA Pkinase(340-583) Pkinase(340-583) - Ank_2

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA ACTB PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA NFKB1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA ITGB4 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA MAPK1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RPS6KB1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RAF1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA MAPK3 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PRKCG PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA BRAF PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PRKCB PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PRKCE PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA ADRBK1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PRKCD PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PDPK1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA CHUK PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA CDK1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA CHEK1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RPS6KA2 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA IKBKB PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA HRAS PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RAC1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RAB4A PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RHOA PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA ELAVL1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA CCNB1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PLD1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA TEC PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA GRB10 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA SOS1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA GRB7 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA UBC PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA VCAM1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA NRG2 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA EGFR PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA FER PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA KIT PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA YES1 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA FES PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA PTK2B PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA LCK PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA ERBB4 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA FYN PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA RET PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA SRC PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA JAK2 PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA LYN PRKCA-001 ENST00000578063
b5e61a38-2067-473e-8eb3-0d8c259b7e67 Lung.Lung-SCC PRKCA NFKBIA PRKCA-001 ENST00000578063
Interaction losses with Clinvar proteins
Gene Name
ACTB
BRAF
CHUK
EGFR
ERBB4
HRAS
IKBKB
ITGB4
JAK2
KIT
LCK
MAPK1
NFKB1
NFKBIA
PLD1
PRKCD
PRKCG
RAC1
RAF1
RET
RHOA
SOS1
SRC