dMDT Interaction Network
Protein interaction losses due to MDT switch
| Gene Name | Interaction Lost | Lost Domain (Region) | Lost Domain - Domain Interaction |
|---|---|---|---|
| RAPGEF4 | RAPGEF4-RAPGEF3 | cNMP_binding(63-151) | cNMP_binding(63-151) - cNMP_binding |
| RAPGEF4 | RAPGEF4-RAF1 | cNMP_binding(63-151) | cNMP_binding(63-151) - Pkinase |
| RAPGEF4 | RAPGEF4-RAP1B | RasGEF(771-953) | RasGEF(771-953) - Ras |
| RAPGEF4 | RAPGEF4-RAP1A | RasGEF(771-953) | RasGEF(771-953) - Ras |
| RAPGEF4 | RAPGEF4-APBB1IP | RA(671-743) | RA(671-743) - PH |
Network Density Score: %
The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
| Sample ID | Disease Type | Gene Name 1 | Gene Name 2 | Transcript Name | dMDT |
|---|---|---|---|---|---|
| 785856FC-D042-4B7F-A137-95B17C59B876 | Breast.Breast-AdenoCA | RAPGEF4 | RAPGEF3 | RAPGEF4-003 | ENST00000397085 |
| 785856FC-D042-4B7F-A137-95B17C59B876 | Breast.Breast-AdenoCA | RAPGEF4 | RAF1 | RAPGEF4-003 | ENST00000397085 |
| 785856FC-D042-4B7F-A137-95B17C59B876 | Breast.Breast-AdenoCA | RAPGEF4 | RAP1B | RAPGEF4-003 | ENST00000397085 |
| 785856FC-D042-4B7F-A137-95B17C59B876 | Breast.Breast-AdenoCA | RAPGEF4 | RAP1A | RAPGEF4-003 | ENST00000397085 |
| 785856FC-D042-4B7F-A137-95B17C59B876 | Breast.Breast-AdenoCA | RAPGEF4 | APBB1IP | RAPGEF4-003 | ENST00000397085 |
Interaction losses with Clinvar proteins
| Gene Name |
|---|
| RAF1 |