CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction lost due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain<-->Domain Interaction
RASGRP2 None None
RASGRP2 RASGRP2-RAF1 C1_1(499-550) C1_1(499-550)--Pkinase
RASGRP2 RASGRP2-RASGRP1 C1_1(499-550) C1_1(499-550)--C1_1
RASGRP2 RASGRP2-APBB1IP C1_1(499-550) C1_1(499-550)--PH
RASGRP2 RASGRP2-RRAS RasGEF(153-324) RasGEF(153-324)--Ras
RASGRP2 RASGRP2-RAP1B RasGEF(153-324) RasGEF(153-324)--Ras
RASGRP2 RASGRP2-MRAS RasGEF(153-324) RasGEF(153-324)--Ras
RASGRP2 RASGRP2-HRAS RasGEF(153-324) RasGEF(153-324)--Ras
RASGRP2 RASGRP2-RAP1A RasGEF(153-324) RasGEF(153-324)--Ras
RASGRP2 RASGRP2-NRAS RasGEF(153-324) RasGEF(153-324)--Ras

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Protein Interaction Lost due to the MDT switch in all disease types
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
2654e816-aab9-4945-ba62-3d6181985463 Lymph-BNHL RASGRP2 None RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc Cervix-SCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
8fbcbc02-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
8fbd1d96-ddb8-11e4-ad8f-5ed8e2d07381 Biliary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
56e6f602-0afb-434e-b28e-665d923ad781 Liver-HCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 RAF1 RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 RRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 RAP1B RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 MRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 HRAS RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 RAP1A RASGRP2-008 ENST00000377489
5bd6ca42-16ca-484f-877f-cda4fb3f93a8 Liver-HCC RASGRP2 NRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
72210f6b-6cf2-4875-8ee9-b2f674b11b85 Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
9eb0abf2-cac5-45a3-b3f3-75de94e7ead8 Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
c38294af-7b80-470a-99eb-523f3fafbbaa Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
f72b280c-e0d0-4b08-bfe3-cd868a2f1b4c Ovary-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 RAF1 RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 RASGRP1 RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 APBB1IP RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 RRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 RAP1B RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 MRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 HRAS RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 RAP1A RASGRP2-008 ENST00000377489
7348f1f9-8bcf-41e2-bcb0-743823cac926 Uterus-AdenoCA RASGRP2 NRAS RASGRP2-008 ENST00000377489
Protein Interaction Lost with Proteins annotated in Clinvar
Gene Name
HRAS
MRAS
NRAS
RAF1
RASGRP1