CanIsoNet

CanIsoNet: Disease-specific Isoform Interaction Network

CanIsoNet serves as a gateway to understand the functional role of disease-specific isoform switching events. We provide two main functionalities for the users:
1. Browsing various statistics on disease-specific isoform switching events
2. Exploring and visualising isoform-specific network disruptions in the STRING interaction network

This table shows the percentange of interaction lost for each dMDT in CanIsoNet as a result of indicated pfam domain lost.
List of Lost Domains in dMDT
Disease Type dMDT GeneName Lost Interaction Lost Pfam Lost Domain
Alzheimer's disease ENST00000376497 CLCN6 0.0 None None
Alzheimer's disease ENST00000456453 ABHD5 0.0 None None
Alzheimer's disease ENST00000552962 DCN 0.0 None None
Alzheimer's disease ENST00000365779 MBTPS2 0.0 None None
Alzheimer's disease ENST00000376310 PRICKLE3 0.0 None None
Alzheimer's disease ENST00000555113 UBR7 0.0 None None
Alzheimer's disease ENST00000556298 ANGEL1 0.0 None None
Alzheimer's disease ENST00000538227 PLEKHB1 0.0 None None
Alzheimer's disease ENST00000538352 STRAP 0.0 None None
Alzheimer's disease ENST00000374467 BAK1 0.0 None None
Alzheimer's disease ENST00000521701 EFCAB1 0.0 None None
Alzheimer's disease ENST00000425986 RTN4R 0.0 None None
Alzheimer's disease ENST00000510477 CDH10 6.67 PF01049 Cadherin_C
Alzheimer's disease ENST00000409066 C2orf83 0.0 None None
Alzheimer's disease ENST00000380641 CNTLN 0.0 None None


Citation:
If you use CanIsoNet, please cite the following articles :
Karakulak et al., CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Cancer, BioRxiv, 2021.
Kahraman et al., Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network, Scientific Reports, 2020.
If you have any inquires about CanIsoNet:

Please contact via tuelay.karakulak@usz.ch.

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