CanIsoNet

CanIsoNet: Disease-specific Isoform Interaction Network

CanIsoNet serves as a gateway to understand the functional role of disease-specific isoform switching events. We provide two main functionalities for the users:
1. Browsing various statistics on disease-specific isoform switching events
2. Exploring and visualising isoform-specific network disruptions in the STRING interaction network

This table shows the percentange of interaction lost for each dMDT in CanIsoNet as a result of indicated pfam domain lost.


List of Lost Domains in dMDT
Disease Type dMDT GeneName Lost Interaction Lost Pfam Lost Domain
Uterus.Uterus-AdenoCA ENST00000594769 AC104534.3 0.0 None None
Uterus.Uterus-AdenoCA ENST00000595051 EGLN2 100.0 PF13640 2OG-FeII_Oxy_3
Uterus.Uterus-AdenoCA ENST00000602390 COMMD3-BMI1 0.0 None None
Uterus.Uterus-AdenoCA ENST00000515604 FAM47E-STBD1 0.0 None None
Uterus.Uterus-AdenoCA ENST00000396904 RBAK-RBAKDN 0.0 None None


Citation:
If you use CanIsoNet, please cite the following articles :
Karakulak et al., CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Cancer, BioRxiv, 2021.
Kahraman et al., Pathogenic impact of transcript isoform switching in 1,209 cancer samples covering 27 cancer types using an isoform-specific interaction network, Scientific Reports, 2020.

If you have any inquires about CanIsoNet:

Please contact via tuelay.karakulak@usz.ch.


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