CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction losses due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain - Domain Interaction
UBA52 UBA52-STAM2 ubiquitin(6-74) ubiquitin(6-74) - SH3_1
UBA52 UBA52-AURKA ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-WNK4 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-RAF1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-IRAK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-CDK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-AKT1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-BUB1B ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-WNK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-PLK1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-WNK1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-PAK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-TBK1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-SGK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-TGFBR2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-NEK2 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-SGK1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-MAP3K7 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-TGFBR1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-PRKCZ ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-CDK1 ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-IKBKB ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-AURKB ubiquitin(6-74) ubiquitin(6-74) - Pkinase
UBA52 UBA52-UBE2B ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-UBE2E1 ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-UBE2C ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-UBE2A ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-UBE2D1 ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-UBE2D2 ubiquitin(6-74) ubiquitin(6-74) - UQ_con
UBA52 UBA52-TCEB2 ubiquitin(6-74) ubiquitin(6-74) - ubiquitin
UBA52 UBA52-RPS27A ubiquitin(6-74) ubiquitin(6-74) - ubiquitin
UBA52 UBA52-UBB ubiquitin(6-74) ubiquitin(6-74) - ubiquitin
UBA52 UBA52-UBC ubiquitin(6-74) ubiquitin(6-74) - ubiquitin
UBA52 UBA52-FAU ubiquitin(6-74) ubiquitin(6-74) - ubiquitin
UBA52 UBA52-USP15 ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-USP8 ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-CYLD ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-USP9X ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-USP1 ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-USP34 ubiquitin(6-74) ubiquitin(6-74) - UCH
UBA52 UBA52-CBL ubiquitin(6-74) ubiquitin(6-74) - UBA
UBA52 UBA52-WWP1 ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-NEDD4 ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-SMURF1 ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-ITCH ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-HECW1 ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-NEDD4L ubiquitin(6-74) ubiquitin(6-74) - HECT
UBA52 UBA52-MDM2 ubiquitin(6-74) ubiquitin(6-74) - zf-RanBP
UBA52 UBA52-HGS ubiquitin(6-74) ubiquitin(6-74) - VHS
UBA52 UBA52-UCHL5 ubiquitin(6-74) ubiquitin(6-74) - Peptidase_C12
UBA52 UBA52-PSMD7 ubiquitin(6-74) ubiquitin(6-74) - JAB
UBA52 UBA52-EIF3F ubiquitin(6-74) ubiquitin(6-74) - JAB
UBA52 UBA52-PSMD14 ubiquitin(6-74) ubiquitin(6-74) - JAB
UBA52 UBA52-EIF3H ubiquitin(6-74) ubiquitin(6-74) - JAB
UBA52 UBA52-PSMD1 ubiquitin(6-74) ubiquitin(6-74) - PC_rep
UBA52 UBA52-PSMD2 ubiquitin(6-74) ubiquitin(6-74) - PC_rep
UBA52 UBA52-PSMD4 ubiquitin(6-74) ubiquitin(6-74) - UIM
UBA52 UBA52-TAB3 ubiquitin(6-74) ubiquitin(6-74) - CUE
UBA52 UBA52-SKP1 ubiquitin(6-74) ubiquitin(6-74) - Skp1_POZ
UBA52 UBA52-TCEB1 ubiquitin(6-74) ubiquitin(6-74) - Skp1_POZ
UBA52 UBA52-TSG101 ubiquitin(6-74) ubiquitin(6-74) - UEV
UBA52 UBA52-CUL3 ubiquitin(6-74) ubiquitin(6-74) - Cullin_Nedd8
UBA52 UBA52-CUL1 ubiquitin(6-74) ubiquitin(6-74) - Cullin_Nedd8
UBA52 UBA52-CUL5 ubiquitin(6-74) ubiquitin(6-74) - Cullin_Nedd8
UBA52 UBA52-CUL2 ubiquitin(6-74) ubiquitin(6-74) - Cullin_Nedd8
UBA52 UBA52-VPS36 ubiquitin(6-74) ubiquitin(6-74) - Vps36_ESCRT-II
UBA52 UBA52-RBX1 ubiquitin(6-74) ubiquitin(6-74) - zf-rbx1
UBA52 UBA52-ANAPC11 ubiquitin(6-74) ubiquitin(6-74) - zf-rbx1
UBA52 UBA52-SKP2 ubiquitin(6-74) ubiquitin(6-74) - F-box-like
UBA52 UBA52-FBXL3 ubiquitin(6-74) ubiquitin(6-74) - F-box-like
UBA52 UBA52-BTRC ubiquitin(6-74) ubiquitin(6-74) - F-box-like
UBA52 UBA52-TRIM32 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_UBOX
UBA52 UBA52-DTX4 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_2
UBA52 UBA52-DTX1 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_2
UBA52 UBA52-RNF111 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_2
UBA52 UBA52-TRIM33 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_2
UBA52 UBA52-ZNRF3 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_2
UBA52 UBA52-MIB1 ubiquitin(6-74) ubiquitin(6-74) - zf-C3HC4_3
UBA52 UBA52-XIAP ubiquitin(6-74) ubiquitin(6-74) - zf-C3HC4_3
UBA52 UBA52-TRAF6 ubiquitin(6-74) ubiquitin(6-74) - zf-C3HC4_2
UBA52 UBA52-SH3GL2 ubiquitin(6-74) ubiquitin(6-74) - SH3_9
UBA52 UBA52-SH3KBP1 ubiquitin(6-74) ubiquitin(6-74) - SH3_9
UBA52 UBA52-NHLRC1 ubiquitin(6-74) ubiquitin(6-74) - zf-RING_5
UBA52 UBA52-RPL9 Ribosomal_L40e(78-128) Ribosomal_L40e(78-128) - Ribosomal_L6

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 STAM2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 AURKA UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 WNK4 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 RAF1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 IRAK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CDK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 AKT1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 BUB1B UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 WNK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PLK1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 WNK1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PAK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TBK1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SGK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TGFBR2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 NEK2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SGK1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 MAP3K7 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TGFBR1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PRKCZ UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CDK1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 IKBKB UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 AURKB UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2B UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2E1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2C UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2A UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2D1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBE2D2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TCEB2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 RPS27A UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBB UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UBC UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 FAU UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 USP15 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 USP8 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CYLD UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 USP9X UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 USP1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 USP34 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CBL UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 WWP1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 NEDD4 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SMURF1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 ITCH UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 HECW1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 NEDD4L UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 MDM2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 HGS UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 UCHL5 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PSMD7 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 EIF3F UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PSMD14 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 EIF3H UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PSMD1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PSMD2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 PSMD4 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TAB3 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SKP1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TCEB1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TSG101 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CUL3 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CUL1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CUL5 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 CUL2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 VPS36 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 RBX1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 ANAPC11 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SKP2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 FBXL3 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 BTRC UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TRIM32 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 DTX4 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 DTX1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 RNF111 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TRIM33 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 ZNRF3 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 MIB1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 XIAP UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 TRAF6 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SH3GL2 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 SH3KBP1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 NHLRC1 UBA52-013 ENST00000594527
37725090-996e-4ab2-bbf6-dc3d2970e387 Esophagus.Eso-AdenoCA UBA52 RPL9 UBA52-013 ENST00000594527
Interaction losses with Clinvar proteins
Gene Name
AKT1
AURKA
BUB1B
CBL
CUL3
CYLD
EIF3F
FBXL3
IKBKB
ITCH
MAP3K7
MDM2
MIB1
NEDD4L
NEK2
NHLRC1
RAF1
SH3KBP1
TBK1
TGFBR1
TGFBR2
TRIM32
UBE2A
USP8
USP9X
WNK1
WNK4
XIAP