dMDT Interaction Network
Protein interaction losses due to MDT switch
| Gene Name | Interaction Lost | Lost Domain (Region) | Lost Domain - Domain Interaction |
|---|---|---|---|
| MAP4K2 | MAP4K2-RIPK1 | Pkinase(16-272) | Pkinase(16-272) - Pkinase |
| MAP4K2 | MAP4K2-MAP3K1 | Pkinase(16-272) | Pkinase(16-272) - Pkinase |
| MAP4K2 | MAP4K2-RAB8A | Pkinase(16-272) | Pkinase(16-272) - Ras |
| MAP4K2 | MAP4K2-CDC42 | Pkinase(16-272) | Pkinase(16-272) - Ras |
| MAP4K2 | MAP4K2-RAC1 | Pkinase(16-272) | Pkinase(16-272) - Ras |
Network Density Score: %
The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
| Sample ID | Disease Type | Gene Name 1 | Gene Name 2 | Transcript Name | dMDT |
|---|---|---|---|---|---|
| 310820cc-fc05-45c6-8f04-a44db0828686 | Colon.ColoRect-AdenoCA | MAP4K2 | RIPK1 | MAP4K2-014 | ENST00000433890 |
| 310820cc-fc05-45c6-8f04-a44db0828686 | Colon.ColoRect-AdenoCA | MAP4K2 | MAP3K1 | MAP4K2-014 | ENST00000433890 |
| 310820cc-fc05-45c6-8f04-a44db0828686 | Colon.ColoRect-AdenoCA | MAP4K2 | RAB8A | MAP4K2-014 | ENST00000433890 |
| 310820cc-fc05-45c6-8f04-a44db0828686 | Colon.ColoRect-AdenoCA | MAP4K2 | CDC42 | MAP4K2-014 | ENST00000433890 |
| 310820cc-fc05-45c6-8f04-a44db0828686 | Colon.ColoRect-AdenoCA | MAP4K2 | RAC1 | MAP4K2-014 | ENST00000433890 |