dMDT Interaction Network
Protein interaction losses due to MDT switch
| Gene Name | Interaction Lost | Lost Domain (Region) | Lost Domain - Domain Interaction |
|---|---|---|---|
| RBPJ | RBPJ-NOTCH2 | TIG(366-444) | TIG(366-444) - Ank_2 |
| RBPJ | RBPJ-NOTCH3 | TIG(366-444) | TIG(366-444) - Ank_2 |
| RBPJ | RBPJ-NOTCH1 | TIG(366-444) | TIG(366-444) - Ank_2 |
| RBPJ | RBPJ-NOTCH4 | TIG(366-444) | TIG(366-444) - Ank_2 |
| RBPJ | RBPJ-MAML1 | LAG1-DNAbind(47-178) | LAG1-DNAbind(47-178) - MamL-1 |
| RBPJ | RBPJ-MAML3 | LAG1-DNAbind(47-178) | LAG1-DNAbind(47-178) - MamL-1 |
Network Density Score: %
The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Samples showing lost interactions due to MDT switch
| Sample ID | Disease Type | Gene Name 1 | Gene Name 2 | Transcript Name | dMDT |
|---|---|---|---|---|---|
| SRR19243472 | Alzheimer's disease | RBPJ | NOTCH2 | RBPJ-018 | ENST00000511546 |
| SRR19243472 | Alzheimer's disease | RBPJ | NOTCH3 | RBPJ-018 | ENST00000511546 |
| SRR19243472 | Alzheimer's disease | RBPJ | NOTCH1 | RBPJ-018 | ENST00000511546 |
| SRR19243472 | Alzheimer's disease | RBPJ | NOTCH4 | RBPJ-018 | ENST00000511546 |
| SRR19243472 | Alzheimer's disease | RBPJ | MAML1 | RBPJ-018 | ENST00000511546 |
| SRR19243472 | Alzheimer's disease | RBPJ | MAML3 | RBPJ-018 | ENST00000511546 |