CanIsoNet

Gene Name:

Protein Interaction Network

Interaction losses of dMDT
*only proteins having domain-domain interaction information are taken into consideration
Gene
Name		 # of
Interaction*		 # of Missed
Interaction		 Interaction
Lost		 Domain Int
Lost		 Transcript Name dMDT
ITK 24 24 ITK-LCP2 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-PLCG1 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-BLK SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-ZAP70 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-YES1 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-LCK SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-GRB2 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-GRAP2 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-FYN SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-SRC SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-PLCG2 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-VAV3 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-VAV2 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-FGR SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-SYK SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-HCK SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-TEC SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-SH2D2A SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-LYN SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-VAV1 SH2(239-323)-SH2 ITK-007 ENST00000517779
ITK 24 24 ITK-PIK3CB SH2(239-323)-PI3_PI4_kinase ITK-007 ENST00000517779
ITK 24 24 ITK-PIK3CG SH2(239-323)-PI3_PI4_kinase ITK-007 ENST00000517779
ITK 24 24 ITK-PIK3CD SH2(239-323)-PI3_PI4_kinase ITK-007 ENST00000517779
ITK 24 24 ITK-SOS1 SH3_1(177-223)-PH ITK-007 ENST00000517779

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT

*Transcripts of this gene has been found as dMDT in these disease types

Samples showing lost interactions due to MDT switch
Sample ID Disease Gene Name 1 Gene Name 2 Transcript Name dMDT
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK LCP2 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK PLCG1 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK BLK ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK ZAP70 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK YES1 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK LCK ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK GRB2 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK GRAP2 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK FYN ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK SRC ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK PLCG2 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK VAV3 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK VAV2 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK FGR ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK SYK ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK HCK ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK TEC ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK SH2D2A ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK LYN ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK VAV1 ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK PIK3CB ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK PIK3CG ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK PIK3CD ITK-007 ENST00000517779
93195d2f-5ec5-4f62-8eca-d0d63eff2c96 Blood.Lymph-CLL ITK SOS1 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK LCP2 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK PLCG1 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK BLK ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK ZAP70 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK YES1 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK LCK ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK GRB2 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK GRAP2 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK FYN ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK SRC ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK PLCG2 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK VAV3 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK VAV2 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK FGR ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK SYK ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK HCK ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK TEC ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK SH2D2A ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK LYN ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK VAV1 ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK PIK3CB ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK PIK3CG ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK PIK3CD ITK-007 ENST00000517779
c32b6576-54fc-44e6-accd-6d49e16a42f0 Blood.Lymph-CLL ITK SOS1 ITK-007 ENST00000517779