CanIsoNet

Gene Name:

Protein Interaction Network

Interaction losses of dMDT
*only proteins having domain-domain interaction information are taken into consideration
Gene
Name		 # of
Interaction*		 # of Missed
Interaction		 Interaction
Lost		 Domain Int
Lost		 Transcript Name dMDT
PTPN2 10 10 PTPN2-NCK2 Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-STAT3 Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-NCK1 Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-STAT6 Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-STAT5A Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-STAT1 Y_phosphatase(42-274)-SH2 PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-PDGFRB Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-EGFR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-INSR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-JAK1 Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-015 ENST00000591901
PTPN2 10 0 None None PTPN2-015 ENST00000591901
PTPN2 10 10 PTPN2-NCK2 Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-STAT3 Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-NCK1 Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-STAT6 Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-STAT5A Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-STAT1 Y_phosphatase(42-274)-SH2 PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-PDGFRB Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-EGFR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-INSR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-JAK1 Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-004 ENST00000591115
PTPN2 10 10 PTPN2-NCK2 Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-STAT3 Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-NCK1 Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-STAT6 Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-STAT5A Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-STAT1 Y_phosphatase(42-274)-SH2 PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-PDGFRB Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-EGFR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-INSR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-JAK1 Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-014 ENST00000585666
PTPN2 10 10 PTPN2-NCK2 Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-STAT3 Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-NCK1 Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-STAT6 Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-STAT5A Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-STAT1 Y_phosphatase(42-274)-SH2 PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-PDGFRB Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-EGFR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-INSR Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-012 ENST00000587703
PTPN2 10 10 PTPN2-JAK1 Y_phosphatase(42-274)-Pkinase_Tyr PTPN2-012 ENST00000587703

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT

*Transcripts of this gene has been found as dMDT in these disease types

Samples showing lost interactions due to MDT switch
Sample ID Disease Gene Name 1 Gene Name 2 Transcript Name dMDT
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 NCK2 PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 STAT3 PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 NCK1 PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 STAT6 PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 STAT5A PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 STAT1 PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 PDGFRB PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 EGFR PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 INSR PTPN2-015 ENST00000591901
429f0e9d-c160-4b36-a31b-dab1097c6129 Bladder.Bladder-TCC PTPN2 JAK1 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 NCK2 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 STAT3 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 NCK1 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 STAT6 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 STAT5A PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 STAT1 PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 PDGFRB PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 EGFR PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 INSR PTPN2-015 ENST00000591901
c9e3d4c7-862b-4ef2-9a08-216fc44e0bdc CervixUteri.Cervix-SCC PTPN2 JAK1 PTPN2-015 ENST00000591901
76733f6c-f1c1-4d57-bf7d-87640d3b88f9 Muscle.Bone-Leiomyo PTPN2 - PTPN2-015 ENST00000591901
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 NCK2 PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 STAT3 PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 NCK1 PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 STAT6 PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 STAT5A PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 STAT1 PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 PDGFRB PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 EGFR PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 INSR PTPN2-004 ENST00000591115
44cc1379-e982-4b0d-b2b1-52a0eac6eb20 Ovary.Ovary-AdenoCA PTPN2 JAK1 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 NCK2 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 STAT3 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 NCK1 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 STAT6 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 STAT5A PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 STAT1 PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 PDGFRB PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 EGFR PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 INSR PTPN2-004 ENST00000591115
8d6b2993-255b-4ddb-a324-3d0d7daa87df Ovary.Ovary-AdenoCA PTPN2 JAK1 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 NCK2 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 STAT3 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 NCK1 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 STAT6 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 STAT5A PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 STAT1 PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 PDGFRB PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 EGFR PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 INSR PTPN2-004 ENST00000591115
d3cc0e8f-4fc4-4937-8e40-78bd4cbeb50f Ovary.Ovary-AdenoCA PTPN2 JAK1 PTPN2-004 ENST00000591115
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 NCK2 PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 STAT3 PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 NCK1 PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 STAT6 PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 STAT5A PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 STAT1 PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 PDGFRB PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 EGFR PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 INSR PTPN2-015 ENST00000591901
358984cc-b532-4f00-89f4-dda524469b6d Ovary.Ovary-AdenoCA PTPN2 JAK1 PTPN2-015 ENST00000591901
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 NCK2 PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 STAT3 PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 NCK1 PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 STAT6 PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 STAT5A PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 STAT1 PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 PDGFRB PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 EGFR PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 INSR PTPN2-014 ENST00000585666
1c908135-7fdf-4257-8b9e-92e6aa0850a6 Uterus.Uterus-AdenoCA PTPN2 JAK1 PTPN2-014 ENST00000585666
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 NCK2 PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 STAT3 PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 NCK1 PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 STAT6 PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 STAT5A PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 STAT1 PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 PDGFRB PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 EGFR PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 INSR PTPN2-012 ENST00000587703
2b483617-1fc6-4809-b15c-d48d687ca3b8 Uterus.Uterus-AdenoCA PTPN2 JAK1 PTPN2-012 ENST00000587703