CanIsoNet

Gene Name:

Transcript ID:
Transcript Name:
dMDT Interaction Network

Protein interaction lost due to MDT switch
*only proteins having domain-domain interaction information are taken into consideration
Number of Total Interaction:
Number of Lost Interaction:
Gene Name Interaction Lost Lost Domain (Region) Lost Domain<-->Domain Interaction
STK11 STK11-STRADB Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-RPS6KB1 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-MARK4 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-SIK1 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-SIK2 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-PRKACA Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-BRSK1 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-BRSK2 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-STRADA Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-PRKAA1 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-PRKAA2 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-MST4 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-MARK2 Pkinase(52-309) Pkinase(52-309)--Pkinase
STK11 STK11-KRAS Pkinase(52-309) Pkinase(52-309)--Ras
STK11 STK11-RAC3 Pkinase(52-309) Pkinase(52-309)--Ras
STK11 STK11-HRAS Pkinase(52-309) Pkinase(52-309)--Ras
STK11 STK11-RAC1 Pkinase(52-309) Pkinase(52-309)--Ras
STK11 STK11-NRAS Pkinase(52-309) Pkinase(52-309)--Ras
STK11 STK11-IRS1 Pkinase(52-309) Pkinase(52-309)--PH
STK11 STK11-HSP90AA1 Pkinase(52-309) Pkinase(52-309)--HSP90
STK11 STK11-PPM1A Pkinase(52-309) Pkinase(52-309)--PP2C
STK11 STK11-PTEN Pkinase(52-309) Pkinase(52-309)--DSPc
STK11 STK11-CDKN1A Pkinase(52-309) Pkinase(52-309)--CDI
STK11 STK11-CDC37 Pkinase(52-309) Pkinase(52-309)--CDC37_N
STK11 STK11-PRKAB1 Pkinase(52-309) Pkinase(52-309)--AMPKBI
STK11 STK11-CAB39 Pkinase(52-309) Pkinase(52-309)--Mo25
STK11 STK11-CAB39L Pkinase(52-309) Pkinase(52-309)--Mo25

Network Density Score: %

The local network of this protein has more interaction than % of all proteins in the proteome.
Statistics on dMDT
*This transcript has been found as a dMDT in these diseases
Protein Interaction Lost due to the MDT switch in all disease types
Sample ID Disease Type Gene Name 1 Gene Name 2 Transcript Name dMDT
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 STRADB STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 RPS6KB1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 MARK4 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 SIK1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 SIK2 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PRKACA STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 BRSK1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 BRSK2 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 STRADA STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PRKAA1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PRKAA2 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 MST4 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 MARK2 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 KRAS STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 RAC3 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 HRAS STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 RAC1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 NRAS STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 IRS1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 HSP90AA1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PPM1A STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PTEN STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 CDKN1A STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 CDC37 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 PRKAB1 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 CAB39 STK11-008 ENST00000593219
8f259997-f80c-4516-a7e6-f8c888f008d4 Skin-Melanoma STK11 CAB39L STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 STRADB STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 RPS6KB1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 MARK4 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 SIK1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 SIK2 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PRKACA STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 BRSK1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 BRSK2 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 STRADA STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PRKAA1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PRKAA2 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 MST4 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 MARK2 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 KRAS STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 RAC3 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 HRAS STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 RAC1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 NRAS STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 IRS1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 HSP90AA1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PPM1A STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PTEN STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 CDKN1A STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 CDC37 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 PRKAB1 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 CAB39 STK11-008 ENST00000593219
c970e2a6-4393-4641-9eea-33a022e23c53 Skin-Melanoma STK11 CAB39L STK11-008 ENST00000593219
Protein Interaction Lost with Proteins annotated in Clinvar
Gene Name
HRAS
IRS1
KRAS
NRAS
PRKACA
PTEN
RAC1
RAC3
SIK1
STRADA